The Impact of Age-related Diazinona Toxicity on Blood Glucose, Lipid Profile and Selected Biochemical Indices in Male Rats

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Author(s): Shahnaz Yousefizadeh, Tahereh Farkhondeh, Saeed Samarghandian*.

Journal Name: Current Aging Science

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Abstract:

Diabetes and its complications are age-related diseases. Low-grade inflammation plays the main role in the initiation and progression of aging processes. Diazinon (DZN), an organophosphate pesticide, has been found to induce metabolic disturbances. The present study was designed to investigate the impact of DZN on age-related changes on inflammatory cells, blood glucose concentration, lipid profile, and liver and kidney function indices. Male Wistar rats (2and 16 monthold) were orally administrated with DZN (15 mg/kg) for 4 weeks. The results indicated that DZN administration increased the blood levels of glucose and the percentage of lymphocytes and also serum levels of cholesterol (TChol), triglyceride (TG), low density lipoprotein (LDL-c), aspartate aminotransferase (AST), alanine aminotransferase (ALT), alkaline phosphatase (ALP), lactate dehydrogenase (LDH), creatinine (Cr), urea, and uric acid in the adult and aged rats versus the aged matched control rats (p< 0.001). A marked reduction in high-density lipoprotein (HDL-c) levels, total protein, albumin, and in the percentage of neutrophils was seen in the adult and aged animals exposed to DZN versus the aged matched control rats. DZN also increased the levels of LDL-c and ALT in the aged rats versus adult animals. The present study indicated that DZN deteriorated the serum levels of lipids, glucose, the percentage of inflammatory cells, and also the function of the liver and kidneys. However, the age-dependent effects of DZN on metabolic indices were not be confirmed by the present data.

Keywords: organophosphate, diazinon, liver, kidney, glucose, lipid profile, aging, rat

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(E-pub Ahead of Print)
DOI: 10.2174/1874609812666190416160918

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