Contribution of Major Polyphenols to the Antioxidant Profile and Cytotoxic Activity of Olive Leaves

(E-pub Ahead of Print)

Author(s): Zouhaier Bouallagui* , Asma Mahmoudi , Amina Maalej , Fatma Hadrich , Hiroko Isoda , Sami Sayadi .

Journal Name: Anti-Cancer Agents in Medicinal Chemistry

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Aims: This study was designed to investigate the phytochemical profile and the cytotoxic activities of olive leaves eco-friendly extracts from Chemlali cultivar.

Materials and methods: The Phenolic composition of olive leaves extracts, the antioxidant activity and the cytotoxic effects against MCF-7 and HepG2 cells were determined.

Results: Olive leaves extracts showed relevant total polyphenols contents. Oleuropein was the major detected phenolic compound reaching a concentration of 16.9 mg/ml. The antioxidant potential of the studied extracts varied from 23.7 to 46.5 mM Trolox equivalents as revealed by DPPH and ABTS assays. Cytotoxicity experiments showed similar trends for both HepG2 and MCF-7 cells with the infusion extract being the most active.

Conclusions: This study denotes that olive leaves may have great potential as endless bioresource of valuable bioactive compounds which may have a wide application.

Keywords: Olea europaea, “Chemlali” cultivar, leaves, phytochemical profile, bioactivities, polyphenols.

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Article Details

(E-pub Ahead of Print)
DOI: 10.2174/1871520619666190416101622
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