Background: Primary aldosteronism is one of the most common causes of secondary
hypertension. Patients with this endocrine syndrome are at increased cardiovascular risk, higher
than hypertensive individuals with equal blood pressure levels.
Objectives: The study aimed to thoroughly present and critically discuss the novel insights into the
field of primary aldosteronism, focusing on the clinically meaningful aspects.
Method: We meticulously evaluated existing data in the field of primary aldosteronism in order to
summarize future perspectives in this narrative review.
Results: Novel data suggests that a subclinical form of primary aldosteronism might exist. Interesting
findings might simplify the diagnostic procedure of the disease, especially for the localization of
primary aldosteronism. The most promising progress has been noted in the field of the molecular
basis of the disease, suggesting new potential therapeutic targets.
Conclusion: Several significant aspects are at early stages of evaluation. Future research is essential
to investigate these well-promising perspectives.