Primary Aldosteronism: Novel Insights

(E-pub Ahead of Print)

Author(s): Konstantinos Stavropoulos, Konstantinos Imprialos, Vasilios Papademetriou, Charles Faselis, Kostas Tsioufis, Kyriakos Dimitriadis, Michael Doumas*.

Journal Name: Current Hypertension Reviews

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Background: Primary aldosteronism is one of the most common causes of secondary hypertension. Patients with this endocrine syndrome are at increased cardiovascular risk, higher than hypertensive individuals with equal blood pressure levels.

Objectives: The study aimed to thoroughly present and critically discuss the novel insights into the field of primary aldosteronism, focusing on the clinically meaningful aspects.

Method: We meticulously evaluated existing data in the field of primary aldosteronism in order to summarize future perspectives in this narrative review.

Results: Novel data suggests that a subclinical form of primary aldosteronism might exist. Interesting findings might simplify the diagnostic procedure of the disease, especially for the localization of primary aldosteronism. The most promising progress has been noted in the field of the molecular basis of the disease, suggesting new potential therapeutic targets.

Conclusion: Several significant aspects are at early stages of evaluation. Future research is essential to investigate these well-promising perspectives.

Keywords: primary aldosteronism, arterial hypertension, secondary hypertension, cardiovascular disease, subclinical aldosteronism, CXCR4 PET scan, KCNJ5 mutations, SIAH1. 

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(E-pub Ahead of Print)
DOI: 10.2174/1573402115666190415155512

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