Role of Natural Product in Modulation of Drug Transporters and New Delhi Metallo-β Lactamases

Author(s): Brinda Chandar*, Debdutta Bhattacharya*.

Journal Name: Current Topics in Medicinal Chemistry

Volume 19 , Issue 10 , 2019

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Abstract:

A rapid growth in drug resistance has brought options for treating antimicrobial resistance to a halt. Bacteria have evolved to accumulate a multitude of genes that encode resistance for a single drug within a single cell. Alternations of drug transporters are one of the causes for the development of resistance in drug interactions. Conversely, the production of enzymes also inactivates most antibiotics. The discovery of newer classes of antibiotics and drugs from natural products is urgently needed. Alternative medicines play an integral role in countries across the globe but many require validation for treatment strategies. It is essential to explore this chemical diversity in order to find novel drugs with specific activities which can be used as alternative drug targets. This review describes the interaction of drugs with resistant pathogens with a special focus on natural product-derived efflux pump and carbapenemase inhibitors.

Keywords: Multi-drug resistance, β-lactamases, NDM-1, Efflux pump, Herbal drug, Drug transporters.

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VOLUME: 19
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