Sustained-release systems made by biodegradable polymers for protein and peptide
drug delivery have received considerable attention by academic researchers and major pharmaceutical
companies around the world. Various types of biodegradable materials, including
natural and synthetic polymers, have been applied to form protein and peptide drug carriers.
Among these material candidates, poly lactic acid (PLA) and poly lactic-co-glycolic acid
(PLGA) are the most commonly used biodegradable materials in the development of protein
and peptide microspheres. In addition, many microsphere preparation technologies, including
spray drying, coacervation, multiple emulsion solvent evaporation method and microporous
membrane emulsification have been developed for microspheres preparation. In this review,
we particularly summarize and briefly introduce the materials and methods that are used to
fabricate microspheres as protein delivery systems. The existing opportunities and challenges
for successful protein delivery are also discussed.
Keywords: Sustained-release system, Protein and peptide drugs, Microspheres, Drug delivery, Microporous membrane emulsification technology
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