The current review focuses on the comprehensive studies of platinum-based complexes that
are known to exhibit anticancer properties. The research on metal-particle work has helped in treating
sicknesses which plays an imperative part in therapeutic bioinorganic science. Understanding the biochemistry
of the detoxification mechanism of metals can help in advancing as well as enhancing the
anticancer property of metal complexes for several types of a tumour. The classifications of complexes
discussed have been done on the basis of Platinum oxidation states and binding sites of the ligands.
Further background and current status of Pt(IV) complexes are briefly explained along with a special
reference to Structural Activity Relationships and Mode of Action. The coordination chemistry of
Pt(IV) has been summarised and Pt(IV) complexes are reviewed on the basis of binding of Pt(IV) with
Human Serum Albumin and DNA. Finally, the results were summarized and concluded emphasizing on
the most important features.
Keywords: Platinum complexes, anticancer, Structural Activity Relationships, Human Serum Albumin, DNA
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