HLA-B27 is a Risk Factor for Rheumatoid Arthritis: Suggestion for an Evidence-based Update

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Author(s): Seyyed Amir Yasin Ahmadi , Reza Mohammadrezaei-Khorramabadi , Saber Abbaszadeh , Jafar Rezaian , Farhad Shahsavar* .

Journal Name: Current Pharmacogenomics and Personalized Medicine (Formerly Current Pharmacogenomics)

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Previously, association of human leukocyte antigen (HLA)-B27 with ankylosing spondylitis has been investigated as original and meta-analysis studies. However the association of HLA-B27 with rheumatoid arthritis is not currently investigated as a meta-analysis. Hence in this letter we intend to perform a brief meta-analysis on this association. Although there were some studies on the association of RA and HLA-B27, however there was not a pooled odds ratio reported in text books. Based on this brief meta-analysis we can report number 2.687 as the odds ratio of this association. It shows that this association is neither sensitive nor specific, but can be an idea for pharmacogenomics and personalized medicine as an independent risk factor. Such other associations should be reported numerically and updated in text books.

Keywords: HLA-B27, rheumatoid arthritis, meta-analysis, personalized medicine, human leukocyte antigen, immunogenic peptides

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(E-pub Ahead of Print)
DOI: 10.2174/1875692117666190408113012