Most of the active pharmaceutical ingredient used in the management of disease
have poor water solubility and offer grueling problems in drug formulation development
since low solubility is generally associated with poor dissolution characteristics which
leads to poor oral bioavailability. The great challenge for the development of a pharmaceutical
product is to create its new formulation and drug delivery system to limit solubility
problems of existing drug candidate. Limited drug-loading capacity requires a large
amount of carrier material to get appropriate encapsulation of the drug, which is another
major challenge in the development of pharmaceutical product which could be resolved by
developing nanocrystals (NCs). A significant research in the past few years has been done
to develop NCs which helps in the delivery of poorly water soluble drugs via different
routes. The technology could continue to thrive as a useful tool in pharmaceutical sciences
for the improvement of drug solubility, absorption and bioavailability. Many crystalline
compounds have pulled in incredible consideration much of the time, due to their ability to
show good physical and chemical properties when contrasted with their amorphous counterparts.
Nanocrystals have been proven to show atypical properties compared to the bulk.
This review article explores the principles of the important nanocrystallization techniques
including NCs characterization and its application.
Keywords: Nanocrystal (NCs), High pressure homogenization, Milling, NanoPure,
Dissocube, Application, Dissolution, Crystalline state.
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