Effect of Ursodeoxycholic Acid, Lawsonia Inermis and Achillea Millefolium Extracts on Hydatid Cyst Protoscolices

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Author(s): Behnam Sanei, Pouria Tavakoli, Mahboubeh Hadipour, Hossein Yousofi Darani*.

Journal Name: Infectious Disorders - Drug Targets

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Background:Cystic echinococcosis (hydatid cyst) is a zoonotic parasitic infection caused by Echinococcus granulosus, is still an important economic and public health concern in the world. Surgery is the treatment of choice for hydatid Cyst. Use of effective scolicidal agents during surgery of hydatid cyst is essential to reduce the recurrence rate.

Methods: Protoscolices were collected from sheep livers containing hydatid cysts. Various concentration of Ursodeoxycholic acid, Lawsonia inermis and Achillea millefolium extracts were used in different exposure times. The viability of protoscolices was ascertained by 0.05% eosin staining.

Results: Ursodeoxycholic acid had some scolicidal effects. Achillea millefolium showed the best scolicidal activities and at the concentration of 3mg/ml after 5 min of incubation killed all of the protoscolices. And Lawsonia inermis extracts at concentration of the 3mg/ml after 10 min of exposure killed 100% of protoscolices.

Conclusion: Lawsonia inermis and Achillea millefolium extracts are a potent protoscolicidal which may be used as a scolicidal agent during the surgery.

Keywords: Hydatid cyst, surgery, Protoscolices, Ursodeoxycholic acid, Lawsonia inermis, Achillea millefolium

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(E-pub Ahead of Print)
DOI: 10.2174/1871526519666190405142120
Price: $95