Background: SOX15 is a crucial transcription factor involved in the regulation
of embryonic development and in the cell fate determination. It is also an important
mediator of tumorigenesis in cancer.
Methods: Here, we sought to explore the expression patterns and biological functions of
SOX15 in esophageal squamous cell carcinomas (ESCC). SOX15 was found aberrantly
overexpressed in ESCC tumors.
Results: Experimentally, inhibition of SOX15 through RNAi suppressed cell proliferation
in ESCC cells and sensitized cancer cells to paclitaxel, but not to Cisplatin. Moreover,
inhibition of SOX15 significantly repressed the expression of genes associated with
WNT and NOTCH signaling pathways, which may contribute to the increased sensitivity
Conclusion: In conclusion, the current study revealed that inhibition of SOX15 in ESCC
cells sensitizes the ESCC cells to paclitaxel, suggesting that the SOX15 expression level
may predict the therapeutic outcomes for paclitaxel treatment for ESCC.