Background: Compound Fengshiding capsule (CFC), is a Chinese
formulation from herbal origin including Alangium platanifolium, Angelicae dahurica,
Cynanchum paniculatum and Glycyrrhiza uralensis. CFC is widely used as clinical
therapy against rheumatoid arthritis. However, its exact mechanism of action has not
been explored yet.
Methods: In order to explore the synergistic mechanism of CFC, we designed a study
adopting network pharmacology scheme to screen the action targets in relation to the
CFC components. The study analyses target facts of salicin, paeonol, liquiritin and
imperatorin from PubMed database, and explores the potential pharmacological targets
of rheumatoid arthritis, cervical neuralgia and sciatica related diseases for their
Results: The results of boosted metabolic pathway showed that the chemical
components of CFC interrupted many immune-related pathways, thus participating in
immunity regulation of the body and playing a role in the treatment of rheumatism.
Collectively, CFC has apoptotic, oxidative stress modulatory and anti-inflammatory
effects that accumulatively serve for its clinical application against rheumatoid arthritis.
Conclusion: Conclusively, our findings from present study reconnoiters and compacts
systematic theoretical approach by utilizing the network pharmacology mechanism of
four effective components for the treatment of rheumatism indicating sufficient potential
drug targets associated with CFC against rheumatism. These interesting findings
entreaties for further in vitro and in vivo studies on the mechanism of compound active
ingredient against rheumatism.