Revealing the Synergistic Mechanism of Multiple Components in Compound Fengshiding Capsule for Rheumatoid Arthritis Therapeutics by Network Pharmacology

Author(s): Hong Duan*, Ke-feng Zhai*, Ghulam J. Khan, Jie Zhou, Ting-yan Cao, Yu-qi Wu, Ya-ru Zhou, Wen-gen Cao, Gui-zhen Gao, Ling-ling Shan.

Journal Name: Current Molecular Medicine

Volume 19 , Issue 4 , 2019

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Abstract:

Background: Compound Fengshiding capsule (CFC), is a Chinese formulation from herbal origin including Alangium platanifolium, Angelicae dahurica, Cynanchum paniculatum and Glycyrrhiza uralensis. CFC is widely used as clinical therapy against rheumatoid arthritis. However, its exact mechanism of action has not been explored yet.

Methods: In order to explore the synergistic mechanism of CFC, we designed a study adopting network pharmacology scheme to screen the action targets in relation to the CFC components. The study analyses target facts of salicin, paeonol, liquiritin and imperatorin from PubMed database, and explores the potential pharmacological targets of rheumatoid arthritis, cervical neuralgia and sciatica related diseases for their interaction.

Results: The results of boosted metabolic pathway showed that the chemical components of CFC interrupted many immune-related pathways, thus participating in immunity regulation of the body and playing a role in the treatment of rheumatism. Collectively, CFC has apoptotic, oxidative stress modulatory and anti-inflammatory effects that accumulatively serve for its clinical application against rheumatoid arthritis.

Conclusion: Conclusively, our findings from present study reconnoiters and compacts systematic theoretical approach by utilizing the network pharmacology mechanism of four effective components for the treatment of rheumatism indicating sufficient potential drug targets associated with CFC against rheumatism. These interesting findings entreaties for further in vitro and in vivo studies on the mechanism of compound active ingredient against rheumatism.

Keywords: Rheumatoid arthritis (RA), Compound Fengshiding capsule (CFC), multiple components, network pharmacology, oxidative stress, pharmacology.

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Article Details

VOLUME: 19
ISSUE: 4
Year: 2019
Page: [303 - 314]
Pages: 12
DOI: 10.2174/1566524019666190405094125
Price: $58

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