Overview of Cellular Mechanisms and Signaling Pathways of Piceatannol

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Author(s): Yang Cao, Wanli Smith , Liang Yan*, Lingbo Kong *.

Journal Name: Current Stem Cell Research & Therapy

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Stilbenoids are a group of naturally occurring phenolic compounds found in various plant species. They share a common backbone structure known as stilbene. However, differs in the nature and position of substituents have make it possible to produce many derivatives. Piceatannol [PT], a hydroxylated derivative from resveratrol, exerts various biological activities ranging from cancer prevention, cardio-protection, neuro-protection, anti-diabetic, depigmentation and so on. Although positive results were obtained in most cell culture and animal studies, the relevant cellular and molecular mechanisms cytokines and signaling pathway about its biological effects still unclear. Thus, in current review we focus on the latest findings of PT on various cellular biology for better understand the underlying therapeutic mechanisms of PT on various diseases.

Keywords: piceatannol, cellular and molecular mechanism, signaling pathway, cytokines, cell cycle, cell apoptosis

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(E-pub Ahead of Print)
DOI: 10.2174/1574888X14666190402100054
Price: $95

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