Spinal cord injury (SCI) is a devastating event, and there are still no effective therapies currently
available. Neural stem cells (NSCs) have gained increasing attention as promising regenerative
therapy of SCI. NSCs based therapies of various neural diseases in animal models and clinical trials
have been widely investigated. In this review we aim to summarize the development and recent progress
in the application of NSCs in cell transplantation therapy for SCI. After brief introduction on
sequential genetic steps regulating spinal cord development in vivo, we describe current experimental
approaches for neural induction of NSCs in vitro. In particular, we focus on NSCs induced from pluripotent
stem cells (PSCs). Finally, we highlight recent progress on the NSCs, which show great promise
in the application to regeneration therapy for SCI.
Keywords: Spinal cord injury, neural induction, neural stem cell, pluripotent stem cell, patient, macrophages.
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