Lyme Neuroborreliosis - The Mystifying Pitfall: “Neuropathology and Current Therapeutics”

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Author(s): Vishal Chavda , Snehal Patel*.

Journal Name: Recent Patents on Anti-Infective Drug Discovery

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Lyme’s Disease (LD) is a severe rapidly growing broad spectrum chronic infection caused by the bacterium ‘Borrelia (B.) burgdoferi', which can be easily transmitted through the bite of certain species of ticks. The prevalence of LD is swiftly mounting in present scenario in many countries from species to species. Although Lyme’s infection is now detectable via serologic examination of early and late Lyme neuroborreliosis (LNB), the management of persistent symptoms is still fraught with quora of doubt and debate. LD is a multisystem spirochete which results after the dissemination of B. burgdorferi from a dermal inoculation site after a tick bite. Lyme's infection can easily be transmitted to the central nervous system and develop various neurological symptoms due to inflammation and autoimmune response from body delivers to life-threatening “Lyme Borreliosis”. The neurological symptoms are well mixed, late and confusing to be diagnosed easily from other diseases. The use of anti-biotic with post Lyme infection with neurological complications is still a topic of debate. Babesiosisstates, Human ehrlichiosis' the two other diseases, are associated with the same ticks that spread the LD. However, the diagnosed prevalence of human cases is usually much lower than that of actual cases of LD due to misdiagnosed, late diagnosed or undiagnosed by such lateral neuroinfection stage after the tick bite. The current review focuses on the molecular neuropathology and current advancements in LD. There are very few patents or discoveries made on borrelia infection snatches exact attention towards more focused and targeted research for cure.

Keywords: Lyme neuroborreliosis (LNB), Borrelia burgudoferi, Neuro-inflammation, Tick-borne disease, Lyme disease vaccine, current therapeutics, mystifying disease

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(E-pub Ahead of Print)
DOI: 10.2174/1574891X14666190327114641

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