Purpose: Heteroresistance Mycobacterium tuberculosis (MTB) is diverse populations of drug-susceptible and resistant bacteria in a single clinical specimen from tuberculosis (TB) patients. Heteroresistance of MTB is considered a preliminary stage to full resistance. The present study aimed to determine the heteroresistance Mycobacterium tuberculosis in Tabuk province, north of the Kingdom of Saudi Arabia.
Method: GenoType MTBDRplus assay was used to determine mutations associated with isoniazid and rifampicin resistances.
Results: A total number of 46 confirmed M. tuberculosis positive sputum samples were scanned for the presence of heteroresistance. The present study revealed 3 (6.5%) heteroresistance to either rpoB gene alone 2 (4.4%) or both rpoB and inhA genes 1 (2.2%).
Conclusion: The detection of hetroresistance mutations could guide the initiating of an appropriate regimen of treatment.
Keywords: Heteroresistance, Mycobacterium tuberculosis, Drug resistance, rpoB mutation, inhA mutation
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