Emergence of Heteroresistance Mycobacterium tuberculosis in Saudi Arabia

(E-pub Ahead of Print)

Author(s): Eltayib H Ahmed Abakur, Tarig MS Alnour*, Faisel Abuduhier, Fahad MA Albalawi, Khalid AS Alfifi .

Journal Name: Infectious Disorders - Drug Targets

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Abstract:

Purpose: Heteroresistance Mycobacterium tuberculosis (MTB) is diverse populations of drug-susceptible and resistant bacteria in a single clinical specimen from tuberculosis (TB) patients. Heteroresistance of MTB is considered a preliminary stage to full resistance. The present study aimed to determine the heteroresistance Mycobacterium tuberculosis in Tabuk province, north of the Kingdom of Saudi Arabia.

Method: GenoType MTBDRplus assay was used to determine mutations associated with isoniazid and rifampicin resistances.

Results: A total number of 46 confirmed M. tuberculosis positive sputum samples were scanned for the presence of heteroresistance. The present study revealed 3 (6.5%) heteroresistance to either rpoB gene alone 2 (4.4%) or both rpoB and inhA genes 1 (2.2%).

Conclusion: The detection of hetroresistance mutations could guide the initiating of an appropriate regimen of treatment.

Keywords: Heteroresistance, Mycobacterium tuberculosis, Drug resistance, rpoB mutation, inhA mutation

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Article Details

(E-pub Ahead of Print)
DOI: 10.2174/1871526519666190326141550
Price: $95