Cytoprotective Agents to Avoid Chemotherapy Induced Sideeffects on Normal Cells: A Review

Author(s): Seema Rohilla*, Harish Dureja, Vinay Chawla.

Journal Name: Current Cancer Drug Targets

Volume 19 , Issue 10 , 2019

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Graphical Abstract:


Anticancer agents play a vital role in the cure of patients suffering from malignancy. Though, the chemotherapeutic agents are associated with various adverse effects which produce significant toxic symptoms in the patients. But this therapy affects both the malignant and normal cells and leads to constricted therapeutic index of antimalignant drugs which adversely impacts the quality of patients’ life. Due to these adversities, sufficient dose of drug is not delivered to patients leading to delay in treatment or improper treatment. Chemoprotective agents have been developed either to minimize or to mitigate the toxicity allied with chemotherapeutic agents. Without any concession in the therapeutic efficacy of anticancer drugs, they provide organ specific guard to normal tissues.

Keywords: Chemoprotective agents, cytoprotective, malignant, chemotherapeutic agent, palifermin, chemotherapy.

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Year: 2019
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DOI: 10.2174/1568009619666190326120457
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