Progress in Molecularly Imprinted Polymers for Biomedical Applications

Author(s): Jane Ru Choi*, Kar Wey Yong*, Jean Yu Choi, Alistair C. Cowie.

Journal Name: Combinatorial Chemistry & High Throughput Screening

Volume 22 , Issue 2 , 2019

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Abstract:

Background: Molecularly Imprinted Polymers (MIPs), a type of biomimetic materials have attracted considerable interest owing to their cost-effectiveness, good physiochemical stability, favorable specificity and selectivity for target analytes, and long shelf life. These materials are able to mimic natural recognition entities, including biological receptors and antibodies, providing a versatile platform to achieve the desirable functionality for various biomedical applications.

Objective: In this review article, we introduce the most recent development of MIPs to date. We first highlight the advantages of using MIPs for a broad range of biomedical applications. We then review their various methods of synthesis along with their latest progress in biomedical applications, including biosensing, drug delivery, cell imaging and drug discovery. Lastly, the existing challenges and future perspectives of MIPs for biomedical applications are briefly discussed.

Conclusion: We envision that MIPs may be used as potential materials for diverse biomedical applications in the near future.

Keywords: Molecularly imprinted polymers, antibodies, biomedical applications, biosensing, drug delivery, cell imaging, drug discovery.

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VOLUME: 22
ISSUE: 2
Year: 2019
Page: [78 - 88]
Pages: 11
DOI: 10.2174/1386207322666190325115526
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