Objective: Many studies have confirmed that the NSE, S100B and MMP9 were specific markers of cerebral injury. This paper was to evaluate the effect of NSE, S100B and MMP9 on reperfusion after carotid artery stenting (CAS).
Method: We recruited 44 patients who were diagnosed unilateral carotid artery stenosis by digital subtraction angiography (DSA) as the operation group; Blood samples were collected at three time points, T1: preoperative, T2: first postoperative morning, T3: third postoperative morning. 12 patients who were excluded carotid artery stenosis by DSA were enrolled in control group; Blood samples were collected before DSA. The content of NSE, S100B and MMP9 in blood were detected by ELISA. All the operation patients underwent CTP (CT perfusion) at T1 and T3. Four cerebral perfusion parameters: cerebral blood volume (CBV), cerebral blood flow (CBF), mean transit time (MTT) and time to peek (TTP) were compared before and after surgery.
Results: (1) rCBF and rCBV were increased while rMTT and rTTP were decreased after carotid artery stent implantation, and all of them had statistical difference except rCBV. (2)The concentration of NSE, S100B and MMP9 in the serum decreased gradually (T30.05); Within the surgery group, T1 vs T2 and T1 vs T3 were statistically significant (P<0.05); T2 vs T3 had no significance (P>0.05) except MMP9.
Conclusion: NSE, S100B and MMP9 could be used as laboratory biochemical markers to evaluate the improvement of reperfusion after CAS, and complement the imaging methods such as CTP.