Rheumatoid arthritis (RA) is a systemic autoimmune disease accompanied by chronic inflammation. Due to the long-term infiltration in inflammatory sites, joints were steadily deteriorated, eventually resulting in functional incapacitation and disability. Despite of the considerable effect, RA sufferers treated with current drug therapeutic efficacy were exposed to severe side effects. Application of Drug Delivery Systems (DDS) has improved these situations while remaining the problem of limited drug exposure untackled. Stimuli-responsive DDS that are responsive to a variety of endogenous and exogenous stimuli, such as pH, redox status, and temperature, have emerged as a promising therapeutic strategy to optimize the drug release. Herein, we discussed the therapeutic regimes and serious side effects of current RA therapy, as well as focusing on some of the potential stimuli-responsive DDS utilized in RA therapy. Besides, the prospective room in designing DDS for RA treatment were also discussed.
Keywords: Rheumatoid arthritis, Therapeutic approaches, Stimuli-responsive Drug Delivery Systems, pH sensitive, Redox sensitive, Enzyme sensitive, Temperature sensitive.
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