Ag/PdTi3O7 Nano Catalyst Promoted for Developing Novel Indole- Naphthyridine Derivatives as Potent Anticancer Agents

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Author(s): Kishore Kumar Valluri, Tejeswara Rao Allaka, IV Kasi Viswanath*, Nagaraju PVVS.

Journal Name: Current Organocatalysis

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Background: Indole-naphthyridine derivatives are known to exhibit a wide range, attracted for the drug design and synthesis of widely studied interesting class of heterocyclic compounds. It is therefore necessary to devote continuing effort to the identification and development of New Chemical Entities (NCEs) as potential anticancer agents to address this serious health problem.

Methods: Ag-loaded PdTi3O7 nano particles an efficient catalyst for the activation of C-H bond and the formation of both intra molecular C-N bond to form the fused heterocyclic system. The final targets are established by various types of functional groups on aryl acetonitiriles moiety with 2-aminonicotinaldehyde in conventional and microwave irradiation conditions. All the indole-naphthyridine derivatives are characterized by microanalyses, SEM, 1H NMR, 13C NMR and mass spectral techniques.

Results: Interestingly, some of the target compounds possessed significant invitro antitumor activities against human breast cancer cell line MCF-7, human normal cell line HEK293T. Among them, compounds 3c, 3a and 3g and 3e, 3a and 3f exhibited better inhibitory activities against MCF-7 and HEK293T cell respectively than the control DXN.

Conclusion: Our study revealed that the molecular framework presented here could be a useful template for the identification of novel indole-naphthyridine molecules as promising anticancer agents.

Keywords: Indole, naphthyridine, anticancer activity, nano particles, XRD, MTT assay.

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(E-pub Ahead of Print)
DOI: 10.2174/2213337206666190320150346