Crohn’s disease (CD) is an immune-mediated condition characterized by the transmural inflammation
of the gut tissue, associated with progressive bowel damage often leading to surgical intervention.
As operative resection of the damaged segment is not curative, a majority of patients undergoing
intestinal resections for complicated CD present disease recurrence within 3 years after the
intervention. Postoperative recurrence can be defined as endoscopic, clinical, radiological or surgical.
Endoscopic recurrence rates within 1 year exceed 60% and the severity, according to the Rutgeerts’
score, is associated with worse prognosis and can predict clinical recurrence (in up to 1/3 of the patients).
Most importantly, about 50% of patients will undergo a reoperation after 10 years of their first
intestinal resection. Therefore, the prevention of postoperative recurrence in CD remains a challenge
in clinical practice and should be properly managed. We aim to summarize the most recent data on the
definition, risk factors, assessment and treatment of postoperative CD recurrence.
Keywords: Crohn's disease, postoperative recurrence, prevention, surgery treatment, immune-mediated, transmural inflammation.
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