Multi-component Preparation of Pyrazolo[3,4-d]thiazolo[3,2-a]pyrimidines Using Solvent-free and HSBM Techniques

(E-pub Ahead of Print)

Author(s): Seyyed Jalal Roudbaraki, Morteza Ziyaadini, Majid Ghashang*.

Journal Name: Letters in Organic Chemistry

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A simple and clean access to pyrazolo[3,4-d]thiazolo[3,2-a]pyrimidine derivatives using solvent-free and HSBM techniques through the multi-component reaction of 3-methyl-1-phenyl-1H-pyrazol-5-amine, 1-aryl-2-thiocyanatoethan-1-one and aromatic aldehydes is reported. Using 2-hydroxyethan-1-aminium acetate as an ionic liquid get the product in high yields.

Keywords: Pyrazolo[3, 4-d]thiazolo[3, 2-a]pyrimidine, Thiazolo[3, 2-a]pyrimidine; HSBM technique, 2-hydroxyethan-1-aminium acetate, Ionic liquid

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Article Details

(E-pub Ahead of Print)
DOI: 10.2174/1570178616666190319155522
Price: $95