Targeting Breast Cancer Stem Cells (BCSCs) with Liposomal Formulations

Author(s): Sumayah Al-Mahmood*.

Journal Name: Clinical Cancer Drugs

Volume 6 , Issue 1 , 2019

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Abstract:

Breast cancer stem cells (BCSCs) are a small proportion of cells that may be responsible for improving the resistance of cancer cells to the treatment and metastasis of breast cancer (MBC). Nanovehicles such as liposomes are extensively explored for diagnosis, treatment, and imaging of cancer. Targeted therapy with nanoparticles can be used to overcome the chemoresistance problem of cancer stem cells. Liposomes are lipid bilayers nanocarriers that have the ability to inhibit P-glycoprotein to overcome multidrug resistance that makes liposome ideal choice for using in BCSCs therapy. The main objective of this review is to describes novel liposomal formulations that are used in targeting BCSCs helping to improve breast cancer treatment.

Keywords: Breast cancer stem cells, liposomes, drug delivery, nanotechnology, breast cancer, targeted treatment.

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Article Details

VOLUME: 6
ISSUE: 1
Year: 2019
Page: [3 - 7]
Pages: 5
DOI: 10.2174/2212697X06666190318150757

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