Background: The objective of the research was to examine the DPPIV inhibitor activity of synthetic derivatives of 2-aminobenzimidazole derivatives by the in-vivo method.
Methods: Molecular docking was performed using homology model of receptors to identify the binding sites for inhibitory activity of diabetes by means of- CDocker energy using Discovery Studio (DS) 4.5 Novel 2-amino benzimidazole derivatives were synthesized from orthophenylene diamine with cyanogens bromide. The synthesized compounds were identified by IR,1HNMR,13CNMR, and MASS spectroscopic techniques. The products were analyzed for their DPPIV inhibitory effects on Wistar Albino rat.
Result: The results were revealed that benzimidazole with para-aminobenzoic acid exhibit best DPPIV inhibitor activity. 2- amino benzimidazole incorporated with aromatic compounds were synthesized and assessed for their DPP-IV inhibitor activity.
Conclusion: 2- amino benzimidazole with para-aminobenzoic acid can be used as a lead compound for the development of new class of DPPIV inhibitor.