The Role of microRNAs Identified in the Amniotic Fluid

(E-pub Ahead of Print)

Author(s): Fasoulakis Zacharias*, Theodora Marianna, Tsirkas Ioannis, Tsirka Theodora, Kalagasidou Sofia, Inagamova Lola, Papamanolis Valentinos, Blontzos Nikolaos, Kontomanolis N Emmanuel.

Journal Name: MicroRNA

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Aim: The study aimed to provide an overall view of current data considering the presence of microRNAs in amniotic fluid.

Methods: The available literature in MEDLINE, regarding the role of the amniotic fluid in pregnancy and fetal development, was searched for related articles including terms such as “microRNA”, “Amniotic fluid”, “Adverse outcome” and others.

Results: The amniotic fluid has an undoubtedly significant part in fetal nutrition, with a protecting and thermoregulatory role alongside. MicroRNAs have proven to be highly expressed during pregnancy in many body liquids including amniotic fluid and are transferred between cells loaded in exosomes, while they are also implicated in many processes during fetal development and could be potential biomarkers for early prediction of adverse outcomes.

Conclusion: Current knowledge reveals that amniotic fluid microRNAs participate in many developmental and physiological processes of pregnancy including proliferation of fibroblasts, fetal development, angiogenesis, cardioprotection, activation of signaling pathways, differentiation and cell motility, while the expression profile of specific microRNAs has a potential prognostic role in the prediction of Down syndrome, congenital hydronephrosis and kidney fibrosis.

Keywords: Amniotic Fluid, Fetal Development, microRNAs, Pregnancy, Adverse outcomes

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Article Details

(E-pub Ahead of Print)
DOI: 10.2174/2211536608666190318105140
Price: $95

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