Detoxification of Heterocyclic Aromatic Amines by Probiotic to Inhibit Medical Hazards

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Author(s): K. Khosravi-Darani*, F. Barzegar, M. Baghdadi.

Journal Name: Mini-Reviews in Medicinal Chemistry

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Cancer is the second leading factor of human death in the world. Long-term consumption of cooked red meat brings about various types of cancers like colorectal cancer due to formation of heterocyclic aromatic amines (HAAs) during the heating process of meat. There are various solutions for the reduction of these toxicants. The aim of this article is describing probiotic as one of possible strategies for bioremoval of these carcinogenic and mutagenic substances and changing food to functional one as well. The mechanism of mentioned biodetoxification is binding by probiotics, which depends on some variables including the probiotic characteristics, kind and content of mutagens, as well as some properties of media. In this article, after introducing detoxification ability of probiotics and listing of all reported probiotics in this field, the influencing variables are surveyed and finally opportunities and problems are of HAA bioremoval by probiotics are described.

Keywords: Bioremoval, Cancerogenic food, Decontamnation, Heterocyclic Aromatic Amines, Probiotics, HazardsBioremoval, Cancerogenic food, Decontamnation, Heterocyclic Aromatic Amines, Probiotics, Hazards

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(E-pub Ahead of Print)
DOI: 10.2174/1389557519666190318102201
Price: $95

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