One-pot of Three-component Synthesis of Novel Biologically Important 5-Amino-1,3-diaryl-1H-pyrazole-4-carbonitriles Using L-Proline Catalyst and their Antimicrobial Activity

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Author(s): Mohammad Reza Poor Heravi*, Mahdis Danafar, Niloofar Poor Heravi.

Journal Name: Letters in Organic Chemistry

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An expeditious three-component synthesis of of various biologically important heterocyclic compounds 5-amino-1,3-diaryl-1H-pyrazole-4-carbonitriles by condensation of aryl aldehydes, malononitrile and phenylhydrazine derivatives is described. This greener protocol was catalyzed by L-Proline and proceeded efficiently in solvent at room temperature within 2–15 min.

Keywords: Multicomponent reactions, 1H-pyrazole-4-carbonitriles, L-Proline, antimicrobial activity, One-pot of three-component, Organocatalys

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Article Details

(E-pub Ahead of Print)
DOI: 10.2174/1570178616666190315155330
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