Interleukin-23 Blockers: Born to be First-line Biologic Agents in Inflammatory Bowel Disease?

Author(s): Marjorie C. Argollo, Mariangela Allocca, Federica Furfaro, Laurent Peyrin-Biroulet, Silvio Danese*.

Journal Name: Current Pharmaceutical Design

Volume 25 , Issue 1 , 2019


Abstract:

Over the past decades, the advent of anti-TNF agents has dramatically changed the treatment algorithms for IBD. However, primarily and more importantly, secondary loss of response to anti-TNF agents, is often observed. Thus, new treatment options have been actively explored and some have already been incorporated in the current clinical practice. Among the class of anti-cytokine agents, the anti-IL12/IL23 monoclonal antibodies (mAbs) have been first presented, in clinical practice, by the anti-p40 mAb ustekinumab in Crohn’s disease (CD). More selective anti-IL23 agents (anti-p19) have shown efficacy and are being further developed, in contrast to agents inhibiting IL-17 downstream, which have failed in IBD clinical trials despite their clear efficacy in psoriasis.

Keywords: Crohn's disease, IL-23, inflammatory bowel disease, monoclonal antibody anti-IL23, Th17 cell pathway cytokines, ulcerative colitis.

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Article Details

VOLUME: 25
ISSUE: 1
Year: 2019
Page: [25 - 31]
Pages: 7
DOI: 10.2174/1381612825666190313140811
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