Follistatin-like 1 (FSTL1), a secreted glycoprotein, has been shown to participate in regulating
developmental processes and to be involved in states of disease and injury. Spatiotemporal regulation
and posttranslational modifications contribute to its specific functions and make it an intriguing
candidate to study disease mechanisms and potentially develop new therapies. With cardiovascular
diseases as the primary cause of death worldwide, clarification of mechanisms underlying cardiac regeneration
and revascularization remains essential. Recent findings on FSTL1 in both acute coronary
syndrome and heart failure emphasize its potential as a target for cardiac regenerative therapy. With
this review, we aim to shed light on the role of FSTL1 specifically in cardiovascular disease and inflammation.
Keywords: Follistatin-Like 1, FSTL1, cardiac regeneration, inflammation, cardiovascular diseases, glycoprotein, cardiomyocytes.
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