A Comprehensive Review on the Screening Models for the Pharmacological Assessment of Antiulcer Drugs

(E-pub Ahead of Print)

Author(s): A P Mishra * , A Bajpai , S Chandra .

Journal Name: Current Clinical Pharmacology

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Abstract:

Background: Due to inappropriate diet, smoking, alcohol consumption, regular use of drugs like NSAIDs, sedentary lifestyle, one may feel upper abdominal pain which may be the predictor of the gastrointestinal disorder called Peptic Ulcer. When an imbalance occurs between the defensive factor and aggressive factor of the stomach, ulcer formation in the esophageal lining, stomach, or duodenum takes place. This leads to the formation of small sores that causes pain. Another condition that synergizes the abdominal pain is vomiting, which looks like coffee grounds, blood in the stool, black or tarry stools. This pain may increase after lunch or dinner. This problem persists that often lead to the gastroenterologist's consultation.

Objective: There are many antiulcer screening models present for the determination of antiulcer activity of the drug molecule. The main objective of this study is to find which model is best for the determination of antiulcer activity.

Methods: A literature search was conducted on the databases namely Science direct, and PubMed with the help of the combination of different keywords: "Anti-ulcer", "In-vitro models", and "In-vivo models". The search was customized by applying the appropriate filters so as to get the most relevant articles to meet the objective of this review article.

Result: There are different research and review papers present on antiulcer screening models for the determination of antiulcer activity of new drug molecules.

Conclusion: On the basis of our study, we found some useful models for the antiulcer activity of drugs and we suggest that if we use In-vitro and In-vivo methods together, then, we get the most relevant result in our research area.

Keywords: Helicobacter pylori, Proton Pump Inhibitor, Cysteamine, Histamine, NSAIDs

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Article Details

(E-pub Ahead of Print)
DOI: 10.2174/1574884714666190312143846