Trifluoroacetylation of Anilines with Ethyl Trifluoropyruvate Mediated by Copper(I) Chloride

Author(s): Jieyu Zhang , Qiumin Ke , Jiaying Chen , Jian Yu* , Guobing Yan* .

Journal Name: Letters in Organic Chemistry

Volume 16 , Issue 11 , 2019

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Abstract:

A novel copper(I)-mediated trifluoroacetylation of anilines with ethyl trifluoropyruvate as a trifluoroacetylating reagent has been developed. Although this protocol could provide good yields in most cases, the reaction exhibited the obvious electronic and steric effects of substituents. The trace amount of products was only obtained for the substrates with ortho-substituted or electron-deficient groups.

Keywords: Trifluoroacetylation, anilines, ethyl trifluoropyruvate, copper catalysis, cross-coupling, deficient groups.

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Article Details

VOLUME: 16
ISSUE: 11
Year: 2019
Page: [860 - 864]
Pages: 5
DOI: 10.2174/1570178616666190311162001
Price: $58

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