Background: Adiponectin, a well-known adipokine plays a number of regulatory actions
in human body metabolism. Decreased levels of adiponectin have been reported in type 2 diabetes
mellitus, cardiovascular diseases, metabolic syndrome and hypertension. Coenzyme Q10 (Co Q10)
is a fat-soluble antioxidant substance which has been reported to be effective in several metabolic
disturbances such as insulin resistance and inflammation.
Objective: Present systematic review and meta-analysis were performed to assess the effects of
CoQ10 supplementation on adiponectin serum level.
Methods: A comprehensive search was performed in electronic databases including EMBASE,
Google scholar, and PubMed up to January 2018. A meta-analysis of eligible studies was performed
using random effects model to estimate pooled effect size of CoQ10 supplementation on adiponectin.
Results: A total of 209 subjects were recruited from 5 eligible studies. Meta-analysis did not suggest
any significant effect of CoQ10 supplementation on adiponectin serum level (0.240 mg/dl,
95%CI: -0.216, 0.696, P= 0.303), without significant heterogeneity between included studies (I2=
40.9%, p= 0.149).
Conclusion: Although present meta-analysis did not indicate any significant effects of CoQ10 supplementation
on serum adiponectin levels but future long-term dose-response trials are needed before
any firm conclusion.