Assessment of Hepatoprotective and Antiulcer Activity of Launaea aspleniifolia Hook in Laboratory Animals

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Author(s): Sadik Ali*, Anup Maiti, Vishal Kumar Vishwakarma, Sivakumar Ajay.

Journal Name: Current Bioactive Compounds

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Background: Launea asplenifolia Hook, (Family Asteraceae) is used traditionally in Indian system of medicine to treat leucoderma. This study was conducted to evaluate the hepatoprotective and antiulcer effects using methanolic extract of Launea asplenifolia Hook (MELA).

Methods: The MELA in dose of 200 and 400 mg/kg body weight (b.w.) was administered orally, daily for 7 days to prevent the acetaminophen induced hepatotoxicity and peptic ulcer. In order to determine the antioxidant enzymes activity, various enzymatic parameters including alanine aminotransferase (ALT), aspartate aminotransferase (AST), total bilirubin (TBL), direct bilirubin (DBL), alkaline phosphatase (ALP), total protein (TP), albumin (ALB), high density lipoproteins (HDL), random glucose test (RBS), serum creatinine levels (SCL), direct bilirubin (DBL) were determined. Further, the histopathology of tissue and various gastric secretion parameter like free acidity, total acidity ulcer score, % ulcer inhibition, gastric volume, pH, Na+ and K+, histopathology were determined in PL-induced ulcer model.

Result: MELA showed dose dependent hepatoprotective and ulcer protective effect in acetaminophen induced hepatotoxicity and antiulcer activity. Furthermore, tissue antioxidant parameter such as reduced Malondialdehyde (MDA), histopathology were also investigated. MELA were more potent in controlling the all serological parameter of liver like ALT, AST, TBL, DBL, ALP, HDL, RBS, SCL, TP and ALB in a dose dependent manner (P<0.05) induced by Acetaminophen. Apart from this antiulcer activity, of MELA was confirmed by low level of ulcer index along with reduction of free acidity, total acidity ulcer score, % ulcer inhibition, gastric volume, Na+ and an increase K+, pH of gastric content in a dose dependent manner (P<0.05) induced PL model.

Conclusion: The results indicated that MELA protects significant dose dependent from injuries induced in liver and stomach. These protective effects of MELA can be examined in various other toxicities as alone and in combinations.

Keywords: Acetaminophen, Flavonoids, Pylorus ligation, Biochemical parameters, MDA

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(E-pub Ahead of Print)
DOI: 10.2174/1573407215666190308154713
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