Among the first line anti-tubercular drugs (ATDs), ethambutol has been rarely associated
to cause drug reaction with eosinophilia and systemic symptoms (DRESS) syndrome. A 34-year-old
woman presented in an out-patient department of Dermatology with fever, skin eruptions, eosinophilia,
hyperinflated lung fields and deranged liver enzymes after 35 days of the initiation of ATDs.
The patient recovered completely after stopping ethambutol and administration of topical and systemic
corticosteroids. Based on the available evidences of de-challenge and re-challenge of suspected
drugs, ethambutol was certainly implicated to cause DRESS syndrome.
Keywords: Drug reaction with eosinophilia and systemic symptoms syndrome, ethambutol, adverse drug reaction, drug-induced
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