Background: Medications currently available for the management of diabetes mellitus are
inconvenient and have some limitations. Thus, investigations for novel approaches are needed to deliver
and target antidiabetics safely to the site of action.
Objective: The present review emphasizes the limitations of conventional antidiabetics and provides
the recent progresses of nanotechnology in the treatment of diabetes mellitus with a special highlight
on the novel nanocarriers methodologies employed as antidiabetic drug delivery systems.
Method: The potential nanocarriers employed for the treatment of diabetes comprise liposomes,
niosomes, self-nanoemulsifying drug delivery systems, polymeric nanoparticles, gold nanoparticles,
dendrimers and micelles. Herbal nanomedicine has also emerged to be a promising way for adequate
delivery of herbal compounds. Other nanotechnology approaches involve the usage of oral insulin, inhalable
insulin, artificial pancreas, and nanopump.
Results: Nanocarriers have proved to lead a successful delivery of antidiabetic medications, aiming at
drug targeting for enhanced efficacy and safety.
Conclusion: These innovative generations of drug delivery systems have important benefits over conventionally
existing ones. The future of nanotechnology in the management of diabetes is still open
with several prospects and will be of pronounced significance.