Assessment of Genotoxicity of Levosimendan in Human Cultured Lymphocytes

Author(s): Abeer M. Rababa'h*, Omar F. Khabour, Karem H. Alzoubi, Dua'a Al-momani, Mera Ababneh.

Journal Name: Current Molecular Pharmacology

Volume 12 , Issue 2 , 2019

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Graphical Abstract:


Background and Objective: Levosimendan is a positive inotropic and a vasodilator agent with pleotropic characteristics that include antioxidation, anti-inflammation and smooth muscle vasodilation.

Methods: In this study, the effects of levosimendan (0, 0.1, 1, 10, and 20 µg/ml) on oxidative DNA damage and sister-chromatid exchanges (SCEs) were evaluated in human cultured lymphocytes.

Results: The results showed that levosimendan increased the frequency of SCEs in all examined concentrations (P<0.01) except for 0.1 µg/ml. On the other hand, levosimendan did not induce oxidative DNA damage as measured by the 8-OHdG biomarker (P > 0.05). In addition, neither mitotic arrest nor proliferation index was affected by levosimendan at all examined doses (P > 0.05).

Conclusion: In conclusion, levosimendan might be associated with increases in sister-chromatid exchanges in cultured human lymphocytes. In vivo studies are required to confirm the present findings.

Keywords: Levosimendan, mitotic index, 8-hydroxy-2-deoxy guanosine (8-OHdG), sister chromatid exchanges.

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Article Details

Year: 2019
Page: [160 - 165]
Pages: 6
DOI: 10.2174/1874467212666190306164926
Price: $58

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