An up-to-date short review of the chalcone methodologies is presented, which is the most
interesting and beneficial for choosing the desired protocol to synthesize suitable derivatives of chalcones.
Chalcones are fluorescent, stable compounds which contribute to the synthesis of various
pharmacologically important heterocyclic structure-based derivatives. Chalcone has displayed a remarkable
curative efficiency to cure several diseases. Several schemes and methodologies have been
reported for employing different catalysts and reagents. The development of improved methodologies
of α, β-unsaturated carbonyl compounds is still on going. In this review, synthetic methodologies
and their recent modification in designing new methods with efficient, economical, eco-friendly
and high yield are discussed.
Keywords: Chalcone, coupling reaction, flavone, indoline, hantzsch ester, pyrazoline.
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