A Review and Analysis on Recent Advancements in Bubble Electrospinning Technology for Nanofiber Production

Author(s): Swayamprakash Patel*, Gayatri Patel.

Journal Name: Recent Patents on Nanotechnology

Volume 13 , Issue 2 , 2019

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Graphical Abstract:


Background: Multiple applications of nanofiber in various segments of science and technology have sparked the interest of innovators to explore the innovative approaches for nanofiber production. The bubble electrospinning technique is the most versatile and simplest approach to scale up the production of nanofiber at the industrial level. Numerous patent applications have been filed with innovations and advancements in the field of bubble electrospinning technique.

Methods: In present work, different patent applications in the field of bubble electrospinning technique, which represents the advancement in bubble electrospinning technology, are searched and analyzed using various paid and free patent databases. The patent search results are compiled, analyzed and individual innovations are studied in detail to bring all the advancements hitherto in the bubble electrospinning technology under the purview of one review article.

Results: The “bubble ws3 electrospin” syntax in the structured search (TAC) facility of the patseer® has revealed most relevant patents on advancement in bubble electrospinning. After applying the family patent filter to the search result (33 patents), ten patents are selected for detailed study. The gist of the invention from each of the patent application or granted patent is recapitulated in this paper, along with their mosaics.

Conclusion: Definite number of inventions are available in the field of bubble electrospinning technique. Inventions, which are disclosed, might have their pros and cons with respect to ease of acceptance by the industrial fraternity for large-scale production depending upon simplicity or complexity of the instrument. There is a profound scope of innovation in the bubble electrospinning technology in the areas like bubble stabilization, size and production rate control and much more.

Keywords: Nanofiber, electrospinning, bubble electrospinning, patent database, bubble fill electrospinning, needle-less electrospinning.

Ramakrishna S, Fujihara K, Teo W-E, Yong T, Ma Z, Ramaseshan R. Electrospun nanofibers: Solving global issues. Mater Today 2006; 9(3): 40-50.
Huang Z-M, Zhang YZ, Kotaki M, Ramakrishna S. A review on polymer nanofibers by electrospinning and their applications in nanocomposites. Comp Sci Technol 2003; 63(15): 2223-53.
Mehta PP, Pawar VS. Electrospun nanofiber scaffolds: Technology and applications. In: Inamuddin, Asiri AM, Mohammad A, eds. Applications of Nanocomposite Materials in Drug Delivery. 1st ed: Cambridge: Woodhead Publishing 2018; pp. 509-73.
Vasita R, Katti DS. Nanofibers and their applications in tissue engineering. Int J Nanomed 2006; 1(1): 15-30.
Khajavi R, Abbasipour M, Bahador A. Electrospun biodegradable nanofibers scaffolds for bone tissue engineering. J Appl Polym Sci 2016; 133(3): 42883.
Burg KJ, Porter S, Kellam JF. Biomaterial developments for bone tissue engineering. Biomaterials 2000; 21(23): 2347-59.
Sun B, Long YZ, Zhang HD, et al. Advances in three-dimensional nanofibrous macrostructures via electrospinning. Prog Polym Sci 2014; 39(5): 862-90.
Mouriño V. Nanoelectrospun matrices for localized drug delivery. In: Asiri AM, Mohammad A, Eds. Applications of Nanocomposite Materials in Drug Delivery. 1st ed. Cambridge: Woodhead Publishing 2018; pp. 491-508.
Ma K, Qiu Y, Fu Y, Ni Q-Q. Electrospun sandwich configuration nanofibers as transparent membranes for skin care drug delivery systems. J Mater Sci Mater Med. 2018: 1-10: 10617-26.
Karczewski A, Feitosa SA, Hamer EI, et al. Clindamycin-modified triple antibiotic nanofibers: A stain-free antimicrobial intracanal drug delivery system. J Endod 2018; 44(1): 155-62.
Deepak A, Goyal AK, Rath G. Nanofiber in transmucosal drug delivery. J Drug Deliv Sci Technol Health Care 2018; 43: 379-87.
Luzhansky D, Burke MD. Nanofiber-Based Drug Delivery. In: Thassu D, Deleers M, Pathak YV, Eds. Nanoparticulate Drug Delivery Systems. 1st ed. Florida: CRC Press 2007; pp. 81-90.
Chen Z, Chen Z, Zhang A, Hu J, Wang X, Yang Z. Electrospun nanofibers for cancer diagnosis and therapy. J Biomater Sci 2016; 4(6): 922-32.
Chen JF, Zhu Y, Lu YT, et al. Clinical applications of nanovelcro rare-cell assays for detection and characterization of circulating tumor cells. Theranostics 2016; 6(9): 1425-39.
Charoenying T, Ngawhirunpat T, Rojanarata T, Tonglairoum P, Opanasopit P. Chitosan/polyvinyl alcohol electrospun nanofiber mats as carriers for arbutin. TJPS 2018; 42: 1-4.
Fathi-Azarbayjani A, Qun L, Chan YW, Chan SYJAP. Novel vitamin and gold-loaded nanofiber facial mask for topical delivery. AAPS PharmSciTech 2010; 11(3): 1164-70.
Sundarrajan S, Tan KL, Lim SH, Ramakrishna S. Electrospun nanofibers for air filtration applications. Procedia Eng 2014; 75: 159-63.
Zhang B, Kang F, Tarascon J-M, Kim J-K. Recent advances in electrospun carbon nanofibers and their application in electrochemical energy storage. Prog Mater Sci 2016; 76: 319-80.
Cooley JF. Apparatus For Electrically Dispersing Fluids. US Patent 1899019625A, 1899
James MW. Method of dispersing fluids. US Patent 1900005905A, 1900
Anton F. Production of artificial fibers. US Patent 19360096226, 1937
Afshari M. Electrospun Nanofibers. 1st ed. Netherlands: Elsevier Science 2016; pp. 1-648.
Arinstein A. Electrospun Polymer Nanofibers. 1st ed. Stanford: Pan Stanford Publishing 2017; pp. 1-197.
Ziabari M, Mottaghitalab V, Haghi AK. Control of electrospun nanofiber diameter using distance transform method. In: Haghi AK, Ed. Electrospun nanofibers research: Recent developments Nanotechnology Science and Technology. 1st ed. New York: Nova Science Publishers 2009; pp. 115-40.
Ramakrishna S, Kazutoshi F, Wee-Eong T, Teik-Cheng L, Zuwei M. An Introduction to Electrospinning and Nanofibers. 1st ed. Singapore: World Scientific 2005; pp. 1-382.
Alghoraibi I, Alomari S. Different methods for nanofiber design and fabrication Handbook of Nanofibers 2018; pp 1-46.
Niu H, Lin T, Wang X. Needleless electrospinning. I.A comparison of cylinder and disk nozzles. JAPS 2009; 114(6): 3524-30.
Wang X, Niu H, Lin T, Wang X. Needleless electrospinning of nanofibers with a conical wire coil. Polym Eng Sci 2009; 49(8): 1582-6.
Wang X, Niu H, Wang X, Lin T. Needleless electrospinning of uniform nanofibers using spiral coil spinnerets. J Nanomater 2012; 2012: 3.
Lu B, Wang Y, Liu Y, et al. Superhigh‐throughput needleless electrospinning using a rotary cone as spinneret. NanoMicro 2010; 6(15): 1612-6.
Dosunmu O, Chase GG, Kataphinan W, Reneker DJN. Electrospinning of polymer nanofibres from multiple jets on a porous tubular surface. Nanotechnology 2006; 17(4): 1123-7.
Varabhas J, Chase GG, Reneker DJP. Electrospun nanofibers from a porous hollow tube. Polymer 2008; 49(19): 4226-9.
Niu H, Gao W, Lin T, Wang X, Kong LJPE. Composite yarns fabricated from continuous needleless electrospun nanofibers. Science 2014; 54(7): 1495-502.
Wang X, Wang XG. Mass Production of Nanofibers from a Spiral Coil. Advances Mater Res 2013; 821-822: 36-40.
Wang X, Wang X, Lin T. Electric field analysis of spinneret design for needleless electrospinning of nanofibers. J Mater Res 2012; 27(23): 3013-9.
Wang X, Zhao Y, Wang H, Cai GM. Electric field and spinning performance in needleless electrospinning. Adv Mater Res 2014; 1048: 26-30.
Wang X, Lin T, Wang X. Scaling up the production rate of nanofibers by needleless electrospinning from multiple ring. Fibers Polym 2014; 15(5): 961-5.
Taylor GI. Disintegration of water drops in an electric field. Proc Royal Soc Lond 1964; 280(1382): 383.
Liu Y, He JH. Bubble electrospinning for mass production of nanofibers. Int J Nonlin Sci Num 2007; 8(3): 393.
Chen R-X, Li Y, He J-H. Mini-review on Bubbfil spinning process for mass-production of nanofibers. Matéria (Rio de Janeiro) 2014; 19: 325-43.
Kishimoto Y. Process for producing microfiber assembly. EP Patent 2048272, 2009.
Kishimoto Y. Process for producing microfiber assembly. US Patent 20090374513, 2010
Sunthornvarabhas J, Reneker DH, Chase GG. Bubble launched electrospinning jets. US Patent 20080679694, 2012.
Jihuan H, Haiyan K, Lixia Z. Bubble electrospinning device. CN Patent 20122254734U, 2012.
Jihuan H, Haiyan K. Bubble electrospinning device. CN Patent 20132833515U, 2014.
Xu L, Zhao J, Wang P, Liu F, He J. Jet flow-controllable bubble electrospinning apparatus. CN Patent 20151012349, 2015.
Smit AE, Sanderson RD. Process for the production of fibers. US Patent 20080595792, 2014.
Gonzalez VAG, Navarro NH, Bautista IBD, Cortez IEM. Bubble electrospinning system and method with high speed flow for the nanofiber production. MX Patent 20150015215, 2017
Yang Z, Jiaxin J, Gaofeng Z, Qinglong M, Jiazheng S, Zhe Z. Autonomous multi-nozzle bubble-electrospinning device. CN Patent 20171060150 2017.
Chien H-S, Chang H-J, Chien H, Chang H. Needleless melt electrostatic spinning apparatus. TW Patent 20110146522, 2013.
Yunze L, Xu Y, Yeming L, Shuxin Y, Jie Z, Xiaoxiong W. Meltbubble electrostatic spinning device. CN Patent 20171333539, 2017.

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Article Details

Year: 2019
Page: [80 - 91]
Pages: 12
DOI: 10.2174/1872210513666190306154923
Price: $58

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