Synthesis of Indole and Benzimidazole Substituted Novel 16-Arylidene Steroid Derivatives

Author(s): Semra Karataş, İrfan Çapan, Süleyman Servi*.

Journal Name: Letters in Organic Chemistry

Volume 16 , Issue 11 , 2019

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Abstract:

Novel aza-heterocyclic substituted dehydroepiandrosterone derivatives were synthesized through a three-step reaction sequence. Some new O-alkylated 4-hydroxybenzaldehydes were synthesized from the reaction of substituted benzaldehydes with dihalogen compounds which have different chain lengths. 16-Arylidene steroids were synthesized from the base-catalyzed aldol condensation of O-alkylated 4-hydroxybenzaldehydes and dehydroepiandrosterone. New indolyl and benzimidazolyl substituted steroid derivatives as hybrid molecules were obtained from the reaction of 16-arylidene steroids with indole or benzimidazole.

Keywords: Dehydroepiandrosterone, indole, benzimidazole, 16-arylidene steroids, O-alkylated 4-hydroxybenzaldehydes, Aldol condensation.

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Article Details

VOLUME: 16
ISSUE: 11
Year: 2019
Page: [884 - 890]
Pages: 7
DOI: 10.2174/1570178616666190305130217
Price: $58

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