Synthesis of Indole and Benzimidazole Substituted Novel 16-Arylidene Steroid Derivatives

Author(s): Semra Karataş , İrfan Çapan , Süleyman Servi* .

Journal Name: Letters in Organic Chemistry

Volume 16 , Issue 11 , 2019

Become EABM
Become Reviewer

Graphical Abstract:


Abstract:

Novel aza-heterocyclic substituted dehydroepiandrosterone derivatives were synthesized through a three-step reaction sequence. Some new O-alkylated 4-hydroxybenzaldehydes were synthesized from the reaction of substituted benzaldehydes with dihalogen compounds which have different chain lengths. 16-Arylidene steroids were synthesized from the base-catalyzed aldol condensation of O-alkylated 4-hydroxybenzaldehydes and dehydroepiandrosterone. New indolyl and benzimidazolyl substituted steroid derivatives as hybrid molecules were obtained from the reaction of 16-arylidene steroids with indole or benzimidazole.

Keywords: Dehydroepiandrosterone, indole, benzimidazole, 16-arylidene steroids, O-alkylated 4-hydroxybenzaldehydes, Aldol condensation.

Rights & PermissionsPrintExport Cite as

Article Details

VOLUME: 16
ISSUE: 11
Year: 2019
Page: [884 - 890]
Pages: 7
DOI: 10.2174/1570178616666190305130217
Price: $58

Article Metrics

PDF: 10