Background: Alzheimer’s disease (AD), a multifaceted disorder, involves complex pathophysiology
and plethora of protein-protein interactions. Thus such interactions can be exploited to develop
Objective: The interaction of dynamin-related protein 1, cellular prion protein, phosphoprotein phosphatase
2A and Mint2 with amyloid β etc., studied recently, may have critical role in progression of the disease.
Our objective has been to review such studies and their implication in design and development of
against the Alzheimer’s disease.
Method: Such studies have been reviewed and critically assessed.
Results: Review has led to show how such studies are useful to develop anti-AD drugs.
Conclusion: There are several PPIs which are current topic of research including Drp1, Aβ interactions
with various targets including PrPC, Fyn kinase, NMDAR and mGluR5 and interaction of Mint2 with
PDZ domain, etc., and thus have potential role in neurodegeneration and AD. Finally, the multi-targeted
approach in AD may be fruitful and opens a new vista for identification and targeting of PPIs in various
cellular pathways to find a cure for the disease.