Protein/ Hormone Based Nanoparticles as Carriers for Drugs Targeting- Protein-Protein Interactions

(E-pub Ahead of Print)

Author(s): Ebtesam Al-Suhaimi*, Vijaya Ravinayagam, B. Rabindran Jermy, Tarhini Mohamad, Abdelhamid Elaissari.

Journal Name: Current Topics in Medicinal Chemistry

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Background: In this review, protein-protein interactions (PPI) were defined, and their behaviors in normal in diseased conditions are discussed. Their status at nuclear, molecular and cellular level was underscored, as for their interference in many diseases. Finally, the use of protein nanoscale structures as possible carriers for drugs targeting PPIs was highlighted. Objective: The objective of this review is to suggest a novel approach for targeting PPIs. By using protein nanospheres and nanocapsules, a promising field of study can be emerged Method: To solidify this argument, PPIs and their biological significance was discussed, same as there role in hormone signaling. After that, we shed the light on the drugs that targets PPI and we suggested the use of nanovectors to encapsulate these drugs to possibly achieve better results. Conclusion: Protein based nanoparticles, due to their advantages, can be suitable carriers for drugs targeting PPIs. This can open a new opportunity in the emerging field of multifunctional therapeutics.

Keywords: Protein-protein interactions, nanoparticles, drug carriers, nano-peptide hormone

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(E-pub Ahead of Print)
DOI: 10.2174/1568026619666190304152320
Price: $95

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