Background: Preeclapmsia (PE) is characterized by early onset symptoms such as
elevated blood pressure, proteinuria and edema in the pregnant woman, and may result in seizures
in the affected female. Currently, there are no therapeutic drugs available to treat this
condition, but there are interventions to regulate the symptoms based on the gestational period
of the fetus, although the largely favored option is delivery of the fetus and placenta.
Objective: A search for biomolecules associated with PE was conducted so as to identify diagnostic
markers and therapeutic leads.
Results: The literature search resulted in the identification of biomolecules such as Corin and
Placental Protein 13 (PP13), among others that are associated with PE. Thereby, giving an
insight into the various mechanistic pathways involved in the causation of PE. However, it is
also evident that PE cannot be solely attributed to any single mechanism but is due to an interplay
of different factors that have led to the development of this disease condition.
Conclusion: The identified biomarkers would ultimately help in understanding this complex
disease and perhaps lead to the discovery of potential effective molecular targets for clinical
trials, thereby providing a valuable therapeutic option for affected pregnant women.