Therapeutic Prospects in Preeclampsia – A Mini-Review

(E-pub Ahead of Print)

Author(s): Nidhi Sharon Das, Shaikali Thameem Dheen, Eng-Ang Ling, Boon Huat Bay, Dinesh Kumar Srinivasan*.

Journal Name: Current Medicinal Chemistry

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Abstract:

Background: Preeclapmsia (PE) is characterized by early onset symptoms such as elevated blood pressure, proteinuria and edema in the pregnant woman, and may result in seizures in the affected woman. Currently, there are no therapeutic drugs available to treat this condition, but there are interventions to regulate the symptoms based on the gestational period of the fetus, although the largely favored option is the delivery of the fetus and placenta.

Objective: A search for biomolecules associated with PE so as to identify diagnostic markers and therapeutic leads.

Results: The literature search resulted in the identification of biomolecules such as corin and placental protein 13 (PP13), among others that are associated with PE. Thereby, giving an insight into the various mechanistic pathways involved in the causation of PE. However, it is also evident that PE cannot be solely attributed to any single mechanism but is due an interplay of different factors that has led to the development of this disease condition.

Conclusion: The identified biomarkers would ultimately help in understanding this complex disease and perhaps lead to the discovery of potential effective molecular targets for clinical trials, thereby providing a valuable therapeutic option for affected pregnant women.

Keywords: Preeclampsia, Hypertension, Biomarkers, Corin, Placental Protein 13, Adenosine.

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Article Details

(E-pub Ahead of Print)
DOI: 10.2174/0929867326666190228115423
Price: $95

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