Background: Pulse Wave Velocity (PWV) is the propagation speed of the wave-induced
along the aorta and arterial tree, each time the heart beats. PWV increases with increased arterial
stiffness, thus establishing it as a reliable prognostic marker for cardiovascular morbidity and mortality.
On the other hand, Total Vascular Resistance (TVR) is the overall resistance offered by systemic
circulation and pulmonary circulation. This resistance needs to be overcome in order to create
the flow of blood through the circulatory system. The goal of this study was to investigate the influence
of different cardiovascular factors on arterial stiffness and vascular resistance in CVD patient
from eastern India population.
Methods: Total of 782 patients with Cardiovascular Disease (CVD) like hypertension, Ischemic
heart disease, Congestive cardiac failure and peripheral arterial disease were included to evaluate
the cardiovascular hemodynamic and non-hemodynamic parameter by oscillometric method and
investigated those factors on PWV and TVR in subjects of both sexes aged between 15 to 87 years.
Results: The old age (> 55 years) was found to have greatest impact on PWV as compared with
younger age group. Systolic Blood Pressure (SBP), Heart Rate (HR), augmentation pressure and
Body Surface Area (BSA) had a positive association with the PWV. Augmentation Index and Body
Mass Index (BMI) had a negative impact on the PWV.
Conclusion: Despite the limitations, like unequal number of male and female participants, wide
variation of the age of the subjects and analyzing association of many factors at a time, our large
and community-based study show individual blood pressure and pulse pressure depending on complex
interaction between large arteries and arterioles. This study sheds light on the relationship between
proximal and distal part (PWV and TVR) of the arterial tree as well as their association with
different hemodynamic and non-hemodynamic parameters.