Extensive attempts have been figure out to decipher the problem associated with solubility of drugs for maximizing bioavailability at targeted sites has been made.More than 40% NCEs (new chemical entities) emerged through modern technology like high throughput screening, combinatorial chemistry, computer aided drug design and the drug discovery process has been dramatically accelerated. Fabrication of materials into the nanodimension changes their physical properties which depict a vivid shift from lab scale optimization studies to scale up focused studies. In addition, this comprehensive review covers physics behind the drug nanocrystals and their properties, different technologies and methods of drug nanocrystal preparation, suspension and its stabilization, nanocrystals in pharmaceutical applications.This review also covers factors affecting nano formulations, post production processing and future prospects.
Keywords: Nanocrystal, Solubility, Nanosuspension, bottom up, top down, stabilizer
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