Inflammatory Biomarkers, Depressive Symptoms and Falls Among the elderly in Panama

Author(s): Gabrielle B. Britton*, Sid E. O'Bryant, Leigh A. Johnson, James R. Hall, Alcibiades E. Villarreal, Diana C. Oviedo, Ambar R. Pérez-Lao, María B. Carreira.

Journal Name: Current Aging Science

Volume 11 , Issue 4 , 2018

Submit Manuscript
Submit Proposal

Graphical Abstract:


Abstract:

Background: Falls are common among elderly adults, and are predictors of hospitalization, institutionalization and mortality.

Objective: The objective of the present study was to examine the relationship between blood-based markers of inflammation and fall events in a sample of elderly Hispanic adults.

Method: Data were collected from 190 participants enrolled in the Panama Aging Research Initiative study who completed baseline clinical and cognitive assessments. A non-fasting blood sample was obtained. Self-reported falls were classified as no falls, single falls or recurrent (two or more) falls reported in the 12 months prior to baseline evaluations. Serum levels of C Reactive Protein (CRP), T-lymphocyte secreting protein (I-309), interleukin 10 (IL-10), interleukin 6 (IL-6) and interleukin 7 (IL-7) were measured. Global cognition was assessed with the Mini Mental State Examination and depressive symptoms were assessed with the Geriatric Depression Scale (GDS-30). Multinomial logistic regression was used to assess the link between inflammation and fall events.

Results: Depressive symptoms, limitations in Instrumental Activities of Daily Living (IADL), IL-7 and I-309 were significantly related to fall events. Elevated levels of IL-7 increased the likelihood of single and recurrent falls, while increased levels of I-309 were associated only with recurrent falls. Greater IADL limitations and depressive symptoms were associated with an increased likelihood of recurrent falls.

Conclusion: There is a lack of research investigating the relationship between inflammatory biomarkers and fall events. These results provide evidence of risk factors for falls in Hispanic older adults, and could serve to guide public health professionals to establish clinical guidelines to reduce fall risks.

Keywords: Aging, disability, inflammation, depression, Hispanics, Latin America.

[1]
Rubenstein LZ. Falls in older people: Epidemiology, risk factors and strategies for prevention. Age Ageing 2006; 35(Suppl. 2): 37-41.
[2]
Tinetti ME, Williams CS. The effect of falls and fall injuries on functioning in community-dwelling older persons. J Gerontol Ser A Biol Sci Med Sci 1998; 53A(2): M112-9.
[3]
Hoffman GJ, Hays RD, Wallace SP, et al. Depressive symptomatology and fall risk among community-dwelling older adults. Soc Sci Med 2017; 178: 206-13.
[4]
Prizer LP, Smith ML, Housman J, et al. Depressive symptomology management and falls among middle aged and older adults. Aging Ment Health 2016; 20(1): 13-21.
[5]
Rao SS. Prevention of falls in older patients. Am Fam Physician 2005; 72(1): 81-8.
[6]
Stevens JA. A CDC compendium of effective fall interventions: What works for community-dwelling older adults. Second edition. Inj Prev 2010; pp. 1-159.
[7]
Sjösten N, Vaapio S, Kivelä SL. The effects of fall prevention trials on depressive symptoms and fear of falling among the aged: A systematic review. Aging Ment Health 2008; 12(1): 30-46.
[8]
Singh T, Newman AB. Inflammatory markers in population studies of aging. Ageing Res Rev 2011; 10(3): 319-29.
[9]
Nicklett EJ, Taylor RJ, Rostant O, et al. Biopsychosocial predictors of fall events among older african americans. Res Aging 2017; 39(4): 501-25.
[10]
Nicklett EJ, Taylor RJ. Racial/ethnic predictors of falls among older adults: The health and retirement study. J Aging Health 2014; 26(6): 1060-75.
[11]
Hanlon JT, Landerman LR, Fillenbaum GG, et al. Falls in African American and white community-dwelling elderly residents. J Gerontol Ser A Biol Sci Med Sci 2002; 57(7): 473-8.
[12]
Stewart WJ, Kowal P, Hestekin H, et al. Prevalence, risk factors and disability associated with fall-related injury in older adults in low- and middle-incomecountries: results from the WHO Study on global AGEing and adult health (SAGE). BMC Med 2015; 13(1): 147.
[13]
Schwartz AV, Hillier TA, Sellmeyer DE, et al. Older women with diabetes have a higher risk of falls: A prospective study. Diabetes Care 2002; 25(10): 1749-54.
[14]
Shumway-Cook A, Ciol MA, Hoffman J, et al. Falls in the Medicare population: Incidence, associated factors, and impact on health care. Phys Ther 2009; 89(4): 324-32.
[15]
Villarreal AE, Grajales S, Lopez L, et al. Cognitive impairment, depression, and cooccurrence of both among the elderly in panama: Differential associations with multimorbidity and functional limitations. Biomed Res Int 2016; 2016: 7 pages.
[16]
Villarreal AE, O’Bryant SE, Edwards M, et al. Serum-based protein profiles of Alzheimer’s disease and mild cognitive impairment in elderly Hispanics. Neurodegener Dis Manag 2016; 6(3): 203-13.
[17]
Villarreal AE, Grajales S, López L, et al. Limitations in activities of daily living among dementia-free older adults in Panama. Ageing Int 2018; 43(2): 1-17.
[18]
Folstein MF, Folstein S, McHugh P. Mini Mental Test. A practical method for grading the cognitive state of patients for the clinician. J Psychiatr Res 1975; 12: 189-98.
[19]
Blesa R, Pujol M, Aguilar M, et al. Clinical validity of the “Mini-Mental State” for Spanish speaking communities. Neuropsychologia 2001; 39(11): 1150-7.
[20]
Yesavage JA, Brink TL, Rose TL, et al. Development and validation of a geriatric depression screening scale: A preliminary report. J Psychiatr Res 1982; 17(1): 37-49.
[21]
Izal M, Montorio I. Adaptation of the geriatric depression scale in spain. Clin Gerontol 1993; 13(2): 83-91.
[22]
O’Bryant SE, Edwards M, Johnson L, et al. A blood screening test for Alzheimer’ s disease. Alzheimers Dement Diag Assess Dis Monit 2016; 3: 1-8.
[23]
O’Bryant SE, Mielke MM, Rissman RA, et al. Blood-based biomarkers in Alzheimer disease: Current state of the science and a novel collaborative paradigm for advancing from discovery to clinic. Alzheimers Dement 2017; 13(1): 45-58.
[24]
O’Bryant SE, Xiao G, Zhang F, et al. Validation of a serum screen for alzheimer’s disease across assay platforms, species, and tissues. J Alzheimers Dis 2014; 42(4): 1325-35.
[25]
Andresen EM, Wolinsky FD, Miller JP, et al. Cross-sectional and longitudinal risk factors for falls, fear of falling, and falls efficacy in a cohort of middle-aged african americans. Gerontologist 2006; 46(2): 249-57.
[26]
de Rekeneire N, Visser M, Peila R, et al. Is a fall just a fall: Correlates of falling in healthy older persons. The health, aging and body composition study. j Am Geriatr Soc 2003; 51(6): 841-6.
[27]
Centers for Disease Control and Prevention. Important facts about falls [Internet]. 2017. Available from. https://www.cdc.gov/homeandrecreationalsafety/falls/adultfalls.html
[28]
Jefferis BJ, Iliffe S, Kendrick D, et al. How are falls and fear of falling associated with objectively measured physical activity in a cohort of community-dwelling older men? BMC Geriatr 2014; 14: 114.
[29]
Sekaran NK, Choi H, Hayward RA, et al. Fall-associated difficulty with activities of daily living in functionally independent individuals aged 65 to 69 in the United States: A cohort study. J Am Geriatr Soc 2013; 61(1): 96-100.
[30]
Deandrea S, Lucenteforte E, Bravi F, et al. Risk factors for falls in community-dwelling older people: A systematic review and meta-analysis. Epidemiology 2010; 21(5): 658-68.
[31]
Iaboni A, Flint AJ. The complex interplay of depression and falls in older adults: A clinical review. Am J Geriatr Psychiatry 2013; 21(5): 484-92.
[32]
Uusi-Rasi K, Patil R, Karinkanta S, et al. Serum 25-hydroxyvitamin D levels and incident falls in older women. Osteoporos Int 2019; 30(1): 93-101.
[33]
Soysal P, Stubbs B, Lucato P, et al. Inflammation and frailty in the elderly: A systematic review and meta-analysis. Ageing Res Rev 2016; 31: 1-8.
[34]
Darvin K, Randolph A, Ovalles S, et al. Plasma protein biomarkers of the geriatric syndrome of frailty. J Gerontol A Biol Sci Med Sci 2014; 69(2): 182-6.
[35]
Passtoors WM, van den Akker EB, Deelen J, et al. IL7R gene expression network associates with human healthy ageing. Immun Ageing 2015; 12(1): 21.
[36]
Kim HR, Hong MS, Dan JM, et al. Altered IL-7Rα expression with aging and the potential implications of IL-7 therapy on CD8+ T-cell immune responses. Blood 2006; 107(7): 2855.
[37]
Banerjee C, Ulloor J, Dillon EL, et al. Identification of serum biomarkers for aging and anabolic response. Immun Ageing 2011; 8: 5.
[38]
McKinney EF, Lyons PA, Carr EJ, et al. A CD8+ T cell transcription signature predicts prognosis in autoimmune disease. Nat Med 2010; 16(5): 586-91.
[39]
Bikker A, Hack CE, Lafeber FPJG, et al. Interleukin-7: A key mediator in T cell-driven autoimmunity, inflammation, and tissue destruction. Curr Pharm Des 2012; 18(16): 2347-56.
[40]
Monson NL, Ireland SJ, Ligocki AJ, et al. Elevated CNS inflammation in patients with preclinical Alzheimer’s disease. J Cereb Blood Flow Metab 2014; 34(1): 30-3.
[41]
Hu WT, Chen-Plotkin A, Arnold SE, et al. Novel CSF biomarkers for Alzheimer’s disease and mild cognitive impairment. Acta Neuropathol 2010; 119(6): 669-78.


Rights & PermissionsPrintExport Cite as


Article Details

VOLUME: 11
ISSUE: 4
Year: 2018
Page: [236 - 241]
Pages: 6
DOI: 10.2174/1874609812666190215125104

Article Metrics

PDF: 28
HTML: 3