Aims and Background: Nosocomial infection is a serious threat to hospitalized patients in healthcare when last-resort antibiotics do not active against pathogenic bacteria. The aim of this study was synthesis and study the effect of Polypropylene imine nanocomposite (PPI/CNT) on Gram-Positive and Gram-Negative bacteria.
Martial and Methods: PPI/CNT component was produced. Surface morphology and structure of PPI/CNT were analyzed by Fourier-transform infrared (FTIR), scanning electron microscopy (SAM) and transmission electron microscopy (TEM). Minimum inhibitory concentration (MIC) of PPI/CNT was determined against various bacteria.
Results: FTIR was showed strong and wider peak binding molecules in the CNT/COOH and PPI/CNT component. PPI/CNT component was denser in comparison to low carbon nanotube according to the SAM test. TEM images showed that carbon nanotube was covered by PPI dots. Staphylococcus epidermidis with 0.0025 µM/ml and Mycobacterium smegmatis with 0.005 µM/ml had the lowest MICs.
Conclusion: Our result indicated that PPI/CNT nanocomposite had good activity against Gram-positive and Gram-negative bacteria. Some of the gram-negative bacteria were tolerant up to highest concentration. With more investigations, it can be used as a new antibacterial component.