Effect of Polypropylene Imine Nanocomposite on Gram-Positive and Gram-Negative Bacteria

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Author(s): Bashir Mohammadpour*, Mohammad Amin Boshagh, Bagher Hayati, Leila Farhadi, Hajar Kashefi, Himen Salimizand.

Journal Name: Anti-Infective Agents

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Aims and Background: Nosocomial infection is a serious threat to hospitalized patients in ‎healthcare when last-resort antibiotics do not active against pathogenic bacteria. The aim of this ‎study was synthesis and study the effect of Polypropylene imine nanocomposite (PPI/CNT) on ‎Gram-Positive and Gram-Negative bacteria.‎

Martial and Methods: PPI/CNT component was produced. Surface morphology and structure of ‎PPI/CNT were analyzed by Fourier-transform infrared (FTIR), scanning electron microscopy ‎‎(SAM) and transmission electron microscopy (TEM). Minimum inhibitory concentration (MIC) ‎of PPI/CNT was determined against various bacteria.‎

Results: FTIR was showed strong and wider peak binding molecules in the CNT/COOH and ‎PPI/CNT component. PPI/CNT component was denser in comparison to low carbon nanotube ‎according to the SAM test. TEM images showed that carbon nanotube was covered by PPI dots. ‎Staphylococcus epidermidis with 0.0025 µM/ml and Mycobacterium smegmatis with 0.005 ‎‎µM/ml had the lowest MICs. ‎

Conclusion: Our result indicated that PPI/CNT nanocomposite had good activity against Gram-positive and Gram-negative bacteria. Some of the gram-negative bacteria were tolerant up to ‎highest concentration. With more investigations, it can be used as a new antibacterial component.‎

Keywords: Polypropylene imine nanocomposite; Electron microscopy; Biomedical applications

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(E-pub Ahead of Print)
DOI: 10.2174/2211352517666190215114534