Therapeutic Potential of Endothelial Colony Forming Cells Derived from Human Umbilical Cord Blood

Author(s): Jing Jia, Baitao Ma, Shaoshuai Wang*, Ling Feng*.

Journal Name: Current Stem Cell Research & Therapy

Volume 14 , Issue 6 , 2019

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Abstract:

Endothelial progenitor cells (EPCs) are implicated in multiple biologic processes such as vascular homeostasis, neovascularization and tissue regeneration, and tumor angiogenesis. A subtype of EPCs is referred to as endothelial colony-forming cells (ECFCs), which display robust clonal proliferative potential and can form durable and functional blood vessels in animal models. In this review, we provide a brief overview of EPCs’ characteristics, classification and origins, a summary of the progress in preclinical studies with regard to the therapeutic potential of human umbilical cord blood derived ECFCs (CB-ECFCs) for ischemia repair, tissue engineering and tumor, and highlight the necessity to select high proliferative CB-ECFCs and to optimize their recovery and expansion conditions.

Keywords: Endothelial colony forming cells (ECFCs), neovascularization, tissue engineering, tumor angiogenesis, vascular homeostasis, peripheral blood.

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Article Details

VOLUME: 14
ISSUE: 6
Year: 2019
Page: [460 - 465]
Pages: 6
DOI: 10.2174/1574888X14666190214162453
Price: $58

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