The Effect of Carrier Matrix and the Method of Preparing Solid Dispersion on Physical State and Solubility of Ibuprofen

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Author(s): Mohd Aftab Alam*, Raishuddin Ali, Fahad Ibrahim Al-Jenoobi, Abdullah M. Al-Mohizea.

Journal Name: Drug Delivery Letters

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Abstract:

Background: The poor solubility of a drug substance is one of the factors which are responsible for poor dissolution and bioavailabity.

Objective: To enhance the solubility of Ibuprofen using different techniques, and to investigate the effect of carrier matrixes and methods of preparing solid dispersion on physical state and solubility of Ibuprofen.

Methods: Fusion method, solvent evaporation and effervescence assisted fusion methods were used to prepared solid dispersions of ibuprofen (IBU). Mannitol, polyethylene-glycol-6000, urea, microcrystalline cellulose, calcium carbonate, sugar spheres, sodium chloride, magnesium oxide, titanium dioxide, citric acid, hydroxypropyl-β-cyclodextrin and β-cyclodextrin were used as carrier matrix. Solid dispersions were characterized using scanning electron microscopy and differential scanning calorimetry (DSC). Solubility of IBU powder and its solid dispersions was investigated in water, acidic buffer (pH-1.2) and in phosphate buffer (pH-6.8).

Results: In some of the solid dispersions IBU lost its crystalline structure and converted into amorphous powder. Scanning electron micrographs and DSC thermograms revealed the absence of IBU crystalline particles in few of the solid dispersion matrixes. Solid dispersion comprising amorphous IBU showed remarkable enhancement in its solubility. The IBU-magnesium oxide solid dispersion showed highest solubility enhancement, followed by IBU-hydroxypropyl-β-cyclodextrin, IBU-polyethylene glycol-6000, IBU-urea and IBU-β-cyclodextrin. The magnesium oxide, hydroxypropyl-β-cyclodextrin and β-cyclodextrin enhances the solubility even at acidic pH. Effervescence assisted fusion technique showed better solubility results than other two technique.

Conclusions: On the basis of present observations it can be suggested that the type of carrier matrix, the method of preparation and the pH of the dispersion plays important role in the solubility of IBU.

Keywords: Ibuprofen, solid dispersion, poorly soluble drugs, BCS Class II and IV, solubility enhancement

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Article Details

(E-pub Ahead of Print)
DOI: 10.2174/2210303109666190214153315
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